Those fresh-faced College Humor boys have put together a great web series called "Bleep Bloop", wherein they film themselves playing video games. It's a lot more fun than it sounds.
I'm as skeptical as anybody when I come across "LOL VIDEOGAMES!" on the internet, but these short videos tend to capture and riff on some of the bizarre nuances of the gaming world without resorting to cliches about how rare girl gamers are and how people who play video games have Cheetos powder on their fingertips. They begin with the premise that gamers aren't funny, but games are. This is where most video game comedy fails.
In this most recent episode, Jeff Rubin and Amir Blumenfeld play Punch Out with an actual professional boxer:
Be sure to check out some of the previous videos, which I thought were generally better than the latest one shown here.
Related Links:
Korean Standup does Starcraft Comedy Routine
You’re Doing Great, Sega: Space Harrier Returns
Digital, Super-Deformed Seth Rogen is Terrifying, Awesome